Cefepime injection — supplier from India to the UK, GCC and Africa.

Cefepime is supplied as 500mg, 1g and 2g lyophilised vials, the three standard hospital strengths across MHRA, EMA, SFDA, MOHAP, SAHPRA and BfArM labelling. The 1g vial reconstitutes with 10ml water for injection or 0.9% NaCl and further dilutes into 50-100ml for a 30-minute IV infusion. Single-vial cartons are standard; 5- and 10-vial hospital outer packs are available against firm tender orders with batch-level traceability on the outer.

Yes. Multiple Indian WHO-GMP partner lines on the M Care roster hold current WHO Prequalification (WHO-PQ) on cefepime, which is the gating requirement for Global Fund, UNICEF Supply Division, GHSC-PSM and comparable UN procurement routes. Where a tender specifies prequalified supply we route to the WHO-PQ lines; where it doesn't, the broader WHO-GMP roster applies. The PQ status is confirmed against the WHO list at point of offer and the prequalification reference appears in the CoPP pack. See NGO and donor procurement.

The neurotoxicity signal is real and the failure mode is almost always inadequate renal dose adjustment. Encephalopathy, non-convulsive status epilepticus, myoclonus and frank seizures have been documented when cefepime accumulates in renal impairment; the FDA issued a formal safety communication in 2012 and case literature has continued. Our destination-language pack inserts carry the renal-dosing table and the neurotoxicity warning verbatim from the reference SmPC. Standard pharmacy guidance: calculate CrCl on day one, recalculate on any change in renal function, reduce frequency to q12h at CrCl 30-60 ml/min, halve the dose at CrCl <30 ml/min, supplementary dose post-dialysis. Symptoms typically appear 1-10 days in and reverse on discontinuation; do not rechallenge.

We routinely ship cefepime into the UK (licensed wholesale and MHRA Specials / named-patient import where the UK supply is constrained), the GCC (UAE, Saudi Arabia, Kuwait, Oman, Qatar, Bahrain through licensed local importers), sub-Saharan Africa (Nigeria, Kenya, Ghana, South Africa through oncology and ICU tender supply plus Global Fund procurement where the tender specifies WHO-PQ), and Germany (§72 AMG import channels with QP certification). We do not supply into India.

Every consignment ships with a batch-specific Certificate of Analysis (HPLC assay, related substances, water content by Karl Fischer, sterility per USP <71>, bacterial endotoxin per USP <85>, particulate matter, reconstituted-solution pH), Method of Analysis, Certificate of Pharmaceutical Product (CoPP), WHO-GMP certificate, manufacturing licence, WHO-PQ confirmation where applicable, Certificate of Origin, destination-language PIL with the renal-impairment neurotoxicity warning, temperature logs, and the WHO AWaRe Watch stewardship reference insert. Full list under anti-infectives.

Cefepime is the WHO EML core agent for empirical febrile neutropenia, so demand is driven by chemotherapy cycle volume rather than emergency-department flow. Procurement should match the haematology-oncology day-unit cycle calendar: estimate cycles per month, multiply by an average 5-7 day empirical course at 2g q8h, and order to a 3-6 month rolling consumption with one month of safety stock. AWaRe Watch classification means batch sizes should be modest and shelf-life pressure should not force consumption; we'll size the first order conservatively and step it up once draw-down is observed. Where ESBL or AmpC resistance prevalence on the local antibiogram is high, factor in carbapenem escalation rates: cefepime use may fall and meropenem use rise, and the order mix should adjust quarter on quarter.

For registered markets with stock on hand, dispatch is typically 5-10 working days from confirmed order. Made-to-order batches, 8-12 weeks inclusive of QC release (HPLC, water content, sterility, endotoxin) and destination-specific artwork approval; lyophilised cephalosporins need full sterility and endotoxin clearance before release. Air-freight to UK or GCC: 3-5 days; sea-freight to Africa: 18-28 days at below-25°C with continuous in-transit logging and on-arrival inspection.