CHEMOTHERAPY DRUGS

Chemotherapy Drugs are commonly known as anti-cancer drugs.

 

Types of chemotherapy drugs are dependent of many factors such as:

Types, Usage, Company & Brands

1. Alka lytic agents: There are several types of alkylating agents used in chemotherapy treatments such as

a) Mustard gas derivative

1. Mechlorethamine:  It is also known as mustine, nitrogen mustard, and HN2, is the prototype anticancer chemotherapy drug.

Brand	Strength	Company	Availability
MUSTRAGEN			NA
VALCHLOR			NA

1. Cyclophosphamide: It is also known as cytophosphane among other names, is a medication used as chemotherapy drugs and to suppress the immune system.

Brand	Strength	Company	Availability
ENDOXAN	500 mg Inj	Baxter	Yes
CYCLOCEL	500 mg Inj	Celon	Yes
PHOSMID	500 mg Inj	Neon	Yes

1. Chlorambucil: This medication is used to treat certain types of cancer (such as leukemia, lymphoma).

Brand	Strength	Company	Availability
CELKERAN	5 mg Tab	Celon	Yes
CLOKERAN	5 mg Tab	Natco	Yes

1. Melphalan: Melphalan is used to treat multiple myeloma (a type of cancer of the bone marrow). Melphalan is also used to treat a certain type of ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed.

Brand	Strength	Company	Availability
ALKACEL	50 mg Inj	Celon	Yes
ALPHALAN	5 mg Tab	Natco	Yes
MEGVAL	50 mg Inj	Emcure	Yes

• Ifosfamide:  is used to treat various cancers (such as testicular cancer).

Brand	Strength	Company	Availability
CELOFOS	1 gm & 2 gm Inj	Celon	Yes
FOSFA	1 gm & 2 gm Inj	Getwell Pharma	Yes
IPAMIDE	1 gm & 2 gm Inj	Fresinius Kabi	Yes

b) Ethylenimines: These are derived from ethylenimine, which is a three-pointed ring of two carbon atoms and a nitrogen atom. Ethylenimine is also called aziridine.

i) Thiotepa: Thiotepa is used to treat the bladder to treat bladder cancer. Thiotepa is also used with other medications to prevent rejection of a stem cell transplant.

Brand	Strength	Company	Availability
			N/A
			N/A
			N/A

ii) Hexamethylmelamine:  It is used as a second line agent in ovarian cancer.

Brand	Strength	Company	Availability
			N/A
			N/A
			N/A

c) Alkylsulfonates:  Alkyl sulfonates are commonly used for the separation of water-soluble basic analytes.

1. Busulfan: Busulfan is chemotherapy drugs in use since 1959. It is a cell cycle non-specific alkylating antineoplastic.

Brand	Strength	Company	Availability
BUCELON	60 mg Inj & 2 mg Tab	Celon	Yes
BUFATAS	60 mg Inj	Intas	Yes
EMSULFAN	60 mg Inj	Emcure	Yes

d) Hydrazine and Triazines: It is used as an antioxidant, an oxygen scavenger.

1. Altretamine: It is used to treat cancer of the ovaries.

Brand	Strength	Company	Availability
			N/A
			N/A
			N/A

1. Procarbazine: Procarbazine is used in combination with other medications to treat certain types of Hodgkins disease (types of cancer that begin in a type of WBC that normally fights infection).

Brand	Strength	Company	Availability
HODPRO	50 mg Capsule	Neon	Yes

1. Dacarbazine: Dacarbazine is used to treat certain types of cancer, such as skin cancer and Hodgkin’s disease.

Brand	Strength	Company	Availability
CELDAZ	200 mg Inj	Celon	Yes
DABAZ	200 mg Inj	Intas	Yes
DACAREX	200 mg Inj	Alkem	Yes

1. Temozolomide: It is used to treat certain types of brain tumours.

Brand	Strength	Company	Availability
GLIOZ	100 mg Cap	Dr. Reddy’s	Yes
TEMONAT	100 mg Cap	Natco	Yes
NUBLAST	100 mg Cap	Zydus Cadila	Yes

• Nitrosureas:  A group of cancer drugs called alkylating agents because they act by the process of alkylation to inhibit DNA repair. The nitrosoureas can cross the blood-brain barrier and are used to treat brain tumours.
• Carmustine: This medication is used to treat certain types of cancer (including multiple myeloma, brain tumor, Hodgkin’s disease, non-Hodgkin’s lymphoma).

Brand	Strength	Company	Availability
CONSIUM	100 mg Inj	Emcure	Yes
CARMUTHER	100 mg Inj	Therdose Pharma	Yes
NITSUM	100 mg Inj	Celon	Yes

• Lomustine: Lomustine is used to treat certain types of brain tumours.

Brand	Strength	Company	Availability
MOOSTIN	40 mg Cap	Miracalus Pharma	Yes
LOMAT	40 mg Cap	Neon	Yes
LOMTIN	40 mg Cap	Dr. Reddy’s	Yes

• Streptozocin:  treating metastatic cancer of the pancreatic islet cells.

Brand	Strength	Company	Availability
			N/A
			N/A
			N/A

• Metal salts:
• Carboplatin: It is used to treat ovarian cancer.it is also used for other types of cancer, including lung, head and neck, endometrial, esophageal, bladder, breast, and cervical; central nervous system or germ cell tumors; osteogenic sarcoma.

Brand	Strength	Company	Availability
CARBOPLATIN	450 mg & 150 mg Inj	Pfizer	Yes
KEMOCARB	450 mg & 150 mg Inj	Fresinius Kabi	Yes
STRICARB	450 mg & 150 mg Inj	Mylan	Yes

1.  Cisplatin: Treatment of  bladder cancer,metastatic ovarian cancer, and metastatic testicular cancer. Testicular, ovarian, bladder, head and neck, esophageal, small and non-small cell lung, breast, cervical, stomach and prostate cancers.

Brand	Strength	Company	Availability
KEMOPLAT	50 mg & 10 mg Inj	Fresinius Kabi	Yes
CELPLAT	50 mg & 10 mg Inj	Celon	Yes
STRITIN	50 mg & 10 mg Inj	Mylan	Yes

1. Oxaliplatin: to treat advanced cancer of the colon and rectum.

Brand	Strength	Company	Availability
OXITAN	100 mg & 50 mg Infusion	Fresinius Kabi	Yes
CELDACH	100 mg & 50 mg Infusion	Celon	Yes
DACOTIN	100 mg & 50 mg Infusion	Dr. Reddy’s	Yes

•  Plant alkaloids: They are from certain types of plants. The plant alkaloids are cell-cycle specific.  This means they attack the cells during various phases of division.
• Vinca alkaloids: It is made from the periwinkle plant .

Vincristine,

Brand	Strength	Company	Availability
BIOCRISTIN AQ	1 mg Inj	Biochem	Yes
VINLON	1 mg Inj	Celon	Yes
CYTOCRISTIN	1 mg Inj	Cipla	Yes

Vinblastine

Brand	Strength	company	Availability
CHEMOBLAST	10 mg Inj	Neon	Yes
CYTOBLASTIN	10 mg Inj	Cipla	Yes
VBLASTIN	10 mg Inj	Chandra Bhagat Pharma	Yes

Vinorelbine.

Brand	Strength	Company	Availability
VINELBINE	10 mg & 50 mg Inj	Fresinius Kabi	Yes
NEOBEN	10 mg & 50 mg Inj	Neon	Yes
ZORELBIN	10 mg & 50 mg Inj	Alkem	Yes

ii) Taxanes: It is made from the bark of the Pacific Yew tree .  They are also known as antimicrotubule agents.

   Paclitaxel

Brand	Strength	Company	Availability
INTAXEL	100 mg	Fresinius Kabi	Yes
ABRAXANE	100 mg	Biocon	Yes
CELTAX	100 mg	Celon	Yes

  Docetaxel

Brand	Strength	Company	Availability
DAXOTEL	80 mg & 120 mg	Fresinius Kabi	Yes
DOCETERO	80 mg & 120 mg	Hetero Drugs	Yes
TAXOTERE	80 mg & 120 mg	Emcure	Yes

1. Podophyllotoxins: They are derived from the May apple plant.

• Etoposide

Brand	Strength	Company	Availability
ETOLON	100 mg Inj	Celon	Yes

• Tenisopide

Brand	Strength	Company	Availability
			N/A
			N/A
			N/A

.

1. Camptothecan analogs are derived from the Asian “Happy Tree” (Camptotheca acuminata), also known as topoisomerase inhibitors, used in certain types of chemotherapy. 
2. Irinotecan

Brand	Strength	Company	Availability
IRINOTEL	40 mg & 100 mg	Fresinius Kabi	Yes

• Topotecan.

Brand	Strength	Company	Availability
			N/A
			N/A
			N/A